Types of hereditary cancer

Hereditary cancer type

The most common types of hereditary cancer are breast cancer, ovarian cancer, colon cancer and uterine cancer. Although more than 39% 1 of people will get some type cancer in their lifetime, remember that hereditary cancers are far less common than random, or sporadic, cancers Lynch syndrome - hereditary non-polyposis colorectal cancer. This can result from damage or mutations in one of five different genetic sequences. Li-Fraumeni syndrome - an extremely rare condition that can cause many cancers including sarcomas, brain cancers, breast cancers, and leukemia

Which cancers are hereditary? - Canadian Cancer Societ

  1. For example, breast cancer and ovarian cancer run together in families with hereditary breast and ovarian cancer syndrome (HBOC). Colon and endometrial cancers tend to go together in Lynch syndrome (also known as hereditary non-polyposis colorectal cancer, or HNPCC)
  2. the presence of physical signs which are known to be associated with hereditary cancer (such as moles and melanoma, or polyps and colon cancer), and certain rare types of cancer
  3. There are two main types of inherited cancer mutations that increase the risk of developing a more severe cancer type down the line. Those two cancer mutations are BRCA1 and BRCA2. Women who inherit the BRCA1 cancer mutation have an increased risk of developing ovarian and breast cancer
  4. Examples include inherited variants in PALB2 (associated with increased risks of breast and pancreatic cancers), CHEK2 (breast and colorectal cancers), BRIP1 (ovarian cancer), and RAD51C and RAD51D (ovarian cancer). Who should consider genetic testing for cancer risk

Table of different genes and the hereditary cancers that

Inherited mutations in the BRCA1 and BRCA2 genes are associated with hereditary breast and ovarian cancer syndrome, which is a disorder marked by an increased lifetime risk of breast and ovarian cancers in women. Several other cancers have been associated with this syndrome, including pancreatic and prostate cancers, as well as male breast cancer Hereditary Colon Cancer . Hereditary colon cancer caused by a single gene mutation represents about 6 percent of colon cancer cases. Personal and family history and cancer types in a family help us to determine the likelihood of a hereditary colon cancer syndrome and, if a syndrome is suspected, which gene(s) should be analyzed Papillary thyroid cancer is the most common type and this type is rarely caused by an inherited faulty gene. Medullary thyroid cancer and related syndromes. Medullary thyroid cancer is a rare type of thyroid cancer. Between 3 and 10 out of every 100 thyroid cancers (3 to 10%) are this type Other hereditary cancers. For people with other cancer types, we now have testing options that did not exist previously. For example, there are now panels available that check 19 genes for hereditary kidney cancer and 13 genes for hereditary pancreatic cancer Several of the most common cancers can be attributed to inherited genetic mutations. Ovarian, breast, pancreas, stomach, colon, prostate, endometrial, kidney, and melanoma skin cancers are thought to have a significant inherited piece, says Ross. There are other rarer cancers too

Understanding Hereditary Cancer. Below you will find links to web sites and video's that provide basic information on hereditary cancer, cancer definitions, risk factors, and prevention. It is generally accepted that 5-10% of all Cancers are hereditary. This means that mutations in specific genes are passed from one blood relative to another Five main types of cancer affect a woman's reproductive organs: cervical, ovarian, uterine, vaginal, and vulvar. As a group, they are referred to as gynecologic cancers. Head and Neck Cancers. Cancers of the head and neck include cancers that start in several places in the head and throat, not including brain cancers or cancers of the eye Hereditary diffuse gastric cancer Hirschsprung disease ganglioneuroblastoma Langerhans cell histiocytosis Li-Fraumeni syndrome Lynch syndrome - Not a rare disease Multiple endocrine neoplasia type 1 Multiple endocrine neoplasia type 2A Multiple endocrine neoplasia type 2B MYH-associated polyposis Oslam syndrome Paraneoplastic Neurologic. All cancer is triggered by altered genes. However, only five to 10 per cent of cancers are actually hereditary. Heredity may sometimes appear to be the reason for a cancer, especially when the same types of cancers run in families. Cancers with a genetic component. These cancers do appear to have some genetic link: Breast cancer; Bowel cancer. The type of tissue where your breast cancer arises determines how the cancer behaves and what treatments are most effective. Parts of the breast where cancer begins include: Milk ducts. Ductal carcinoma is the most common type of breast cancer. This type of cancer forms in the lining of a milk duct within your breast

Hereditary Colorectal Cancer | NEJM

HBOC is an inherited genetic condition. This means that the cancer risk is passed from generation to generation in a family. There are 2 primary genes linked with most families who have HBOC: BRCA1 and BRCA2. BRCA stands for BReast CAncer Genetic cancers are inherited and certain facts help to identify which cancer is genetic. Genes should be identified to know the family history of cancer. This article explains about the family history of cancer, which cancers are genetic, what are genetic cancers, and the symptoms and genes related to genetic cancer Genetic counseling is often recommended for people who develop cancer at a young age (for example, breast cancer before age 45). It may also be recommended for people with multiple close family members who have had the same type of cancer. We take many risk factors into consideration when evaluating someone for a potential hereditary risk of.

Hereditary Cancer Syndromes MD Anderson Cancer Cente

  1. Abstract Colorectal cancer is one of the most frequent neoplasms in western countries; it is the third most common cancer in men after prostate and lung cancer and the second most common in women after breast cancer. Colorectal cancer is usually sporadic but in a small proportion is hereditary
  2. Heredity represents the strongest risk factor for ovarian cancer with disease predisposing mutations identified in 15% of the tumors. With the aim to identify genetic classifiers for hereditary ovarian cancer, we profiled hereditary ovarian cancers linked to the hereditary breast and ovarian cancer (HBOC) syndrome and the hereditary non-polyposis colorectal cancer (HNPCC) syndrome
  3. g a mass called a tumor. A tumor can be benign, meaning noncancerous, or it can be malignant, meanin
  4. Hereditary Breast and Ovarian Cancer. About 5% to 10% of breast and 10% to 15% of ovarian cancers are hereditary. Hereditary cancer means cancer runs in your family, and could be caused by a change in certain genes that you inherited from your mother or father.. Genes act as instructions and contain information to build and maintain cells in the body. . Humans inherit one set of genes from.

Types of Hereditary Cance

Types of hereditary cancer. There are many types of hereditary cancers which are caused by mutations in different genes. This website provides information on BRCA-associated breast, ovarian and prostate cancers that are caused by mutations in the BRCA1 and BRCA2 genes. Genetic testing and counseling for breast cancer. Relatives of a patient may be at risk for cancer. Get them genetic testing today

Hereditary amyloidosis

Hereditary breast cancer and ovarian cancer . Genes: BRCA1, BRCA2 Related cancer types: Female breast and ovarian cancers, and other cancers, including prostate, pancreatic, and male breast cancer. BRCA1 and BRCA2 are tumor suppressor genes; their protein products are responsible for preventing uncontrolled cell division. Specifically, the BRCA1 and BRCA2 proteins are involved in repairing DNA. Genetic specialists estimate that between 3 and 10 in every 100 cancers (3 to 10%) diagnosed are linked to an inherited faulty gene. But the evidence is not completely clear. Different gene faults increase the risk of different types of cancer Most people with Li-Fraumeni syndrome, a rare genetic condition, have mutations in the TP53 gene, increasing the risk of many different types of cancer. The most common are soft tissue sarcomas (tumors in fat, muscles, nerves, joints, blood vessels, bones or deep skin), breast cancer, leukemia, lung cancer, brain tumors and adrenal gland cancer

Hereditary Cancer - Types Of Genetic Cancer - Cancer Horizon

Hereditary Breast and Ovarian Cancer About 5% to 10% of breast and 10% to 15% of ovarian cancers are hereditary. Hereditary cancer means cancer runs in your family, and could be caused by a change in certain genes that you inherited from your mother or father Some well-known hereditary cancers include BRCA gene-related breast cancers, and colon cancers such as hereditary non-polyposis colon cancer and familial adenomatous polyposis. It's important to remember that these types of inherited mutations only increase the likelihood that a person will develop cancer, in most cases

The contribution of genetic mutations is best regarded as a continuum: in familial breast cancer genetic abnormalities play a minor role in the risk of breast cancer, whereas in hereditary forms, BRCA1, BRCA2 and BRCA3 mutations have a significant impact. Many families, however, find themselves caught at the boundary between these two entities Bile duct cancer Biliary tract cancer Birt-Hogg-Dube syndrome Blastic plasmacytoid dendritic cell Bloom syndrome Blue rubber bleb nevus syndrome Bowen's disease Brain stem cancer Brain tumor, adult Brain tumor, childhood BRCA1 hereditary breast and ovarian cancer syndrome BRCA2 hereditary breast and ovarian cancer syndrome Breast cancer, mal Here are some things that may indicate that someone has a higher risk for hereditary cancer: early-onset cancers (i.e. diagnosed before the age of 50 years), individuals with multiple primary cancers (i.e. 2 or more cancers of separate origin, not the spread of one cancer to other areas of the body) rare types of cancer (i.e. ovarian The major hereditary colon cancer syndromes are Lynch syndrome (previously known as Hereditary Non-Polyposis Colorectal Cancer or HNPCC) and Familial Adenomatous Polyposis (FAP). Other genes have also been implicated in hereditary colon cancer risk People who develop lung cancer at a younger age are more likely to have genetic changes associated with the disease. But a hereditary link to these genetic changes has not been established. Almost all lung cancers in young adults are adenocarcinomas, a type of cancer closely linked to certain acquired (not inherited) genetic mutations. 7

Family Cancer Syndromes - American Cancer Societ

The two hereditary syndromes described thus far each involve an inherited risk for one main type of cancer, either retinoblastoma for individuals inheriting a mutant RB gene or colon cancer for those inheriting a mutant APC gene Other types include carcinoid tumors, gastrointestinal stromal tumors, colorectal lymphoma. Hereditary colorectal cancers, meaning that several generations of a family have had colorectal cancer, include hereditary nonpolyposis colorectal cancer (HNPCC) and familial adenomatous polyposis (FAP). Here is an overview of some of the types of cancer. Hereditary cancer syndromes are associated with up to 10 percent of all cancer diagnoses. The cancer type that develops from a syndrome depends on the mutated or defective gene. For instance, hereditary breast and ovarian cancer syndrome stems from mutations in the BRCA1and/or BRCA2 genes

Innovations in Cancer Care: MRI-Guided Radiotherapy and

What Is Hereditary Cancer? Medical Genetic

  1. A family member with more than 1 type of cancer Family members who had cancer at a younger age than normal for that type of cancer Close relatives with cancers that are linked to rare hereditary cancer syndromes A family member with a rare cancer, such as breast cancer in a male or retinoblastom
  2. Genetic mutation: It is possible that a family may have a single gene mutation that puts certain family members at an increased risk to develop certain types of cancer. The altered gene can be passed from parent to child and results in an inherited predisposition or susceptibility to develop cancer
  3. BRCA1 and BRCA2 genetic mutations Most inherited cases of breast cancer are associated with mutations in two genes: BRCA1 (BReast CAncer gene one) and BRCA2 (BReast CAncer gene two). Everyone has BRCA1 and BRCA2 genes. The function of the BRCA genes is to repair cell damage and keep breast, ovarian, and other cells growing normally
  4. Heredity represents the strongest risk factor for ovarian cancer with disease predisposing mutations identified in 15% of the tumors. With the aim to identify genetic classifiers for hereditary ovarian cancer, we profiled hereditary ovarian cancers linked to the hereditary breast and ovarian cancer (HBOC) syndrome and the hereditary non.
  5. What is a genetic disease or disorder? Learn from a list of genetic diseases that are caused by abnormalities in an individual's genome. There are four main types of genetic inheritance, single, multifactorial, chromosome abnormalities, and mitochondrial inheritance. Genetic testing is available for some genetic diseases

Are most cancers hereditary? - Arizona Oncology Foundatio

Hereditary medullary thyroid cancer is the only feature This subtype constitutes approximately 10-20% of cases of MEN2 MEN2 and Thyroid Findings: Medullary thyroid cancer can develop during childhood or early adulthood and can spread earl Genetic and hereditary risk factors can increase someone's chance of developing kidney cancer. Some rare genetic conditions can also cause kidney cancer. Even though people with these conditions are at a much higher risk, hereditary kidney cancers make up only about 3 to 5% of all kidney cancer

The gene mutations are present in the egg or sperm and cause the disease to be passed from parents to their children. Some examples of hereditary diseases include hemophilia, sickle cell anemia,.. Key Points. Question How often and for what types of variant reclassifications are amended reports issued as part of hereditary cancer genetic testing?. Findings In this retrospective cohort study that included 1.45 million individuals and 1.67 million initial tests, 59 955 amended reports were issued due to variant reclassification. . Among variants initially classified as uncertain. 971. Causes, Inheritance: Cancer gene types, Vogelstein clip 1. Professor Bert Vogelstein, explains that cancer is in essence a genetic disease. It is caused by mutations of genes and there are three types of genes, that contribute to cancer. ID: 971; Source: I

A personal history of two or more types of cancer; A personal history of ovarian cancer; Finally, your family may have another hereditary cancer gene mutation that can be detected with other genetic tests. Researchers are continuing to study gene mutations that increase the risk of cancer and developing new gene tests. If your gene test was. Researchers are studying genetic causes of cancer at a rapid pace, and new genes related to higher cancer risk are being discovered. A gene panel test can look at your DNA for many of these mutations. But remember that not all mutations have the same impact on whether you develop cancer. There are three types of mutations a gene panel can look for Certain types of cancers including breast, ovarian, and colon cancer, are more likely to be inherited within families. Most people with cancer do not develop the disease due to an inherited (also known as hereditary) cause. Inherited forms of cancer make up 5 to 10 percent of all cancer cases

Papillary thyroid cancer chest x ray - wikidoc

Because glioblastoma cells tend to have more genetic abnormalities than the cells of other types of brain cancer, researchers believe multiple genetic mutations may contribute to its development. Genetic testing is an option for individuals who have an inherited condition that may predispose them to developing glioblastoma. Research continue There are several different types of thyroid cancer, which are classified based on how similar they look to normal thyroid cells under a microscope and by the type of cell from which they develop.. Those types include: Papillary carcinoma is the most common type of thyroid cancer, accounting for approximately 80 percent of cases.Papillary carcinomas are slow-growing, differentiated cancers. The ovaries consist of three kinds of cells, and ovarian cancer can stem from these cells. Ovarian cancer is hereditary. And the chance of it being hereditary depends on the type of ovarian cancer. There are numerous genetic factors like mutations that play a role in the inheritance of ovarian cancer. Find the most common gene mutations below Artificial Intelligence Classifies Cancer Types, Predicts Genetic Alterations. July 29, 2020. 0 In particular, in major cancer types such as lung, colorectal, breast, and gastric cancers. Multiple Endocrine Neoplasia type 1 (MEN1) is a rare hereditary endocrine cancer syndrome characterized primarily by tumors of the parathyroid glands (95% of cases), endocrine gastroenteropancreatic (GEP) tract (30-80% of cases), and anterior pituitary (15-90% of cases)

WebMD provides an alphabetical list of various types of cancer - from Adenoid Cystic Carcinoma to Xeroderma Pigmentosu Hereditary Breast Cancer. Breast cancer associated with the passing of abnormal genetic material from a parent to a child is called hereditary breast cancer. About 5 to 10 percent of breast cancer cases are believed to be hereditary. Having a close blood relative (immediate family member) with breast cancer can increase your own risk of breast. Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic Genetic/Familial High-Risk Assessment: Colorectal Lung Cancer Screening. Prostate Cancer Early Detection. Adult Cancer Pain Antiemesis Cancer-Associated Venous Thromboembolic Disease Cancer-Related Fatigue. Treatment by Cancer Type Genetic testing can help you determine if you are at increased risk for developing certain types of cancer. 35 Genes are analyzed by Myriad Genetic Laboratories for hereditary cancer risk. Coverage is excellent! Most insurance companies cover genetic testing at 100% The most common inherited cancer syndromes are hereditary breast and ovarian cancer syndrome, Lynch syndrome (also known as hereditary non-polyposis colorectal cancer), Li-Fraumeni syndrome, PTEN hamartoma tumor syndrome, familial adenomatous polyposis, Von-Hippel Lindau syndrome, and multiple endocrine neoplasia type 1 and type 2. Most of the.

Genetic Testing Fact Sheet - National Cancer Institut

  1. Pages in category Hereditary cancers The following 24 pages are in this category, out of 24 total. This list may not reflect recent changes ()
  2. The types of cancer are based on the specific gene that has an inherited gene mutation. People with an inherited gene mutation leading to an increased chance to develop cancer are said to have hereditary cancer or have a hereditary cancer predisposition
  3. Certain genetic changes, or mutations, can increase a person's chances of developing cancer. These changes, known as hereditary cancer syndromes, can be passed down from parent to child.Hereditary leukemia is one of the newest areas our experts are studying.. Courtney DiNardo, M.D., and genetic counselor Sarah Bannon with MD Anderson's Hereditary Leukemia Clinic are among a handful of.

About 1% to 3% of stomach (gastric) cancers are hereditary diffuse gastric cancers (HDGC). The disorder is caused by mutation in the CDH1 gene. HDGC is an inherited cancer syndrome that leads to an increased risk for both diffuse stomach cancer and lobular breast cancer. People who inherit the. Hereditary cancer 1. HEREDITARY CANCER SYNDROMES • DEFINITION: Change or mutation in a specific gene which may have been inherited and predispose a person to a particular type of cancer There are more than 50 known hereditary cancer syndromes, and 5 to 10 percent of cancers have a hereditary component to them, a release from Billings Clinic says. However, despite this knowledge, testing for these types of cancers in the appropriate populations remains a vastly underused cancer prevention strategy

All cancers are genetic. DNA (deoxyribonucleic acid) is in every cell in our bodies. Each DNA strand contains many genes. All cancers begin when DNA mutations, or changes, cause cells to divide and grow out of control. But this is different from hereditary cancer. Hereditary or familial cancer means that a risk for the disease runs in the family Genetic counselors are available to perform genetic risk assessments, including constructing a pedigree to determine who may benefit from genetic testing. Genetic testing can determine if someone has inherited an alteration in a breast cancer susceptibility gene that would impact the individual's risk of developing certain types of cancer 1 or more Spitz nevi and a close blood relative has (or had) mesothelioma (a type of cancer), meningioma (a type of brain tumor), or melanoma of the eye 1. Positive genetic test for melanoma can provide important information. A genetic test for melanoma can tell you about more than your melanoma risk

The Genetics of Cancer - National Cancer Institut

Throat cancer can actually mean more than one kind of cancer, and each affects a different place in your throat. Learn about the different types, the signs of each one, and how each is treated Lynch syndrome, often called hereditary nonpolyposis colorectal cancer (HNPCC), is an inherited disorder that increases the risk of many types of cancer, particularly cancers of the colon (large intestine) and rectum, which are collectively referred to as colorectal cancer. People with Lynch syndrome also have an increased risk of cancers of the stomach, small intestine, liver, gallbladder.

The invasive nature of this type of cancer makes it highly likely that these cancer cells will spread (metastasize) to other tissues, such as the liver or nearby bones. Symptoms of diffuse gastric cancer occur late in the disease and can include stomach pain, nausea, vomiting, difficulty swallowing (dysphagia), decreased appetite, and weight loss They also showed that the levels of and types of genetic changes varied between cancer types. And even in the same tumour, the genetic makeup of different subclones varied widely The Ins and Outs of Genetic Testing for Cancer Risk. Posted on April 12, 2021. Cancer has many contributing factors, one of which is genetics. Some cancers occur repeatedly among family members and relatives, and it's possible for underlying genetic mutations called variants to be a cause

In a new analysis, researchers have shed light on these hereditary elements across 12 cancer types — showing a surprising inherited component to stomach cancer and providing some needed clarity on the consequences of certain types of mutations in well-known breast cancer susceptibility genes, BRCA1 and BRCA2 different cancer types including stomach and intestine cancer, hepatocellular carcinoma, neoplasms of the breast and the brain, squamous cell lung carcinoma, pancreatic adenocarcinoma, gynecological cancers, chronic lymphocytic leukemia (CLL), and acute myeloid leukemia (AML) (ClinVar variation ID 230256)

A small percentage of the cancers can be truly genetic with identifiable genetic markers. The pattern of familial clustering is more in some cancer like breast cancer, colon cancer, and ovarian caner but less in many other types of cancers like lung cancer, prostate cancer, and esophageal cancer Genetic testing. Genetic testing is the scientific testing of a person's genes and is usually done when someone is at an increased risk of having inherited a changed gene (mutation). Your eligibility for genetic testing will be based on family history and other factors such as a family member having a specific type of cancer and an altered gene is the cause CancerNext is a comprehensive 36-gene panel that identifies inherited risks for at least 8 types of cancers. CancerNext is a comprehensive 36-gene panel that identifies inherited risks for at least 8 types of cancers. CancerNext is a comprehensive 36-gene panel that identifies inherited risks for at least 8 types of cancers

Adult Primary Liver Cancer Treatment - National Cancer

Genetic Cancers & Gene Testing NorthShor

Genetic risks to family members are reassessed based on the genetic test results. Risk Reduction Strategies - Discussion of surveillance and preventative measures will vary depending on the type of cancer, genetic test results and personal and medical family history. Options may include intensive monitoring, medications and surgery Abnormalities in some of the genes in colon cells that control cell growth and death can cause colorectal cancer. Hereditary Non-polyposis Colorectal Cancer (HNPCC), which affects nearly 5 percent of colorectal cancer patients, is characterized by a mutation in an important gene, which is inherited -- or passed from parent to child An inherited colon cancer syndrome. Lynch syndrome, also called hereditary nonpolyposis colorectal cancer (HNPCC), is a syndrome that increases the risk of colon cancer and other cancers, including endometrial cancer. Lynch syndrome is caused by a gene mutation passed from parents to children

Skin Signs of Internal Cancers I | NSC

Inherited genes and cancer types Cancer Research U

There are several types of cancer that can affect the bladder. It's unusual for bladder cancer to run in families, but some types may have a hereditary link Thanks to research funded by the Prostate Cancer Foundation, we now know that some prostate cancers are caused by genetic mutations. In 12%-20% of families, certain cancer-causing genes are passed down from mothers and fathers to sons and daughters. These are referred to as germline genetic mutations

Hereditary Cancers - Signs, Risks & Tests Centura Healt

Cancer genetics 1. S P E A K E R : D R . M D . S H A I F U L H A S S A N S H A M E E M A S S I S T A N T R E G I S T R A R D E P T . O F R A D I O T H E R A P Y D H A K A M E D I C A L C O L L E G E H O S P I T A L INTRODUCTION TO CANCER GENETICS 2. The genetic nature of Cancer Cancer is a complex disease that result from the basic process of. The genetics of ovarian cancer are a complex, ever evolving concept that presents hurdles in classification, diagnosis, and treatment in the clinic. Instead of common driver mutations, genomic instability is one of the hallmarks of ovarian cancer. While ovarian cancer is stratified into different clinical subtypes, there still exists extensive genetic and progressive diversity within each subtype Hereditary thyroid cancer is thyroid cancer that develops in people who have inherited damage to certain genes. People with inherited damage to their RET gene develop medullary thyroid cancer and have a hereditary cancer syndrome called multiple endocrine neoplasia, type II Cancer is a broad term. It describes the disease that results when cellular changes cause the uncontrolled growth and division of cells. Some types of cancer cause rapid cell growth, while others. JScreen, a national public health initiative based out of Emory University School of Medicine's Department of Human Genetics, recently announced a new program that offers at-home testing for 63 cancer susceptibility genes associated with hereditary risks for breast, ovarian, prostate, colorectal, skin and many other cancers

Roswell Park recommends genetic counseling if your physician observes a strong family history of melanoma or pancreatic cancer in at least three members on one side of the family, at least three melanomas developing in one person — with the first occurring before age 45 — or if we diagnose a specific type of unusual mole Myriad Oncology is Dedicated to Providing Answers That Help Guide Cancer Treatment Decisions and Give Patients and Their Families Information on Hereditary Cancer Risk. Myriad Oncology offers a suite of tests for eight different cancer types that provide critical information regarding your or your patients' disease A multi-institutional team of researchers has identified both the genetic abnormalities that drive pre-cancer cells into becoming an invasive type of head and neck cancer and patients who are. Even though the concerned patient is male, if he is BRCA1 positive, his risk for breast cancer (and some other types of cancers) would be increased. Most lung cancer is sporadic, with a strong environmental component, although a familial susceptibility can exist (but the genetic input is not known) Others may want to see a genetic counselor because there is a known genetic cause for cancer in their family, including: Hereditary Breast and Ovarian (HBOC) syndrome (BRCA1 and BRCA2 genes) Lynch syndrome (MLH1, MSH2, MSH6, PMS2, and EPCAM genes) ATM-related breast cancer (ATM gene) Hereditary Diffuse Gastric Cancer syndrome (CDH1 gene

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